abstract：:There is an increasing burden in digestive cancer in the coming years. With the advancement of endoscopic therapy, new molecular target therapy and minimally invasive ablation therapy, the treatment of digestive cancer will become more complicated. In Asia where gastric cancer and hepatocellular carcinoma are still pr...

journal_title：Journal of gastroenterology and hepatology

authors： Sung J

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND AND AIM:Exportin 4 (XPO4) is a recently-discovered candidate tumor-suppressor gene identified in a liver cancer mouse model. To investigate the role of XPO4 in hepatocellular carcinoma (HCC) pathogenesis, we determined XPO4 expression and its correlation to prognosis in human primary HCC. METHODS:The XPO4 m...

journal_title：Journal of gastroenterology and hepatology

authors： Liang XT,Pan K,Chen MS,Li JJ,Wang H,Zhao JJ,Sun JC,Chen YB,Ma HQ,Wang QJ,Xia JC

更新日期：2011-03-01 00:00:00

abstract：:MicroRNAs (miRNAs) are small non-coding RNAs of 19-23 nucleotides that negatively regulate gene expression through binding to the 3'-untranslated regions of target messenger RNAs (mRNAs). Although the miRNA family constitutes only a minor fraction of the human genome, they hold fundamental importance in diverse physio...

journal_title：Journal of gastroenterology and hepatology

authors： Law PT,Wong N

更新日期：2011-03-01 00:00:00

abstract：BACKGROUND AND AIM:Hepatitis E virus (HEV) infection is endemic in several developing countries. Clinical manifestations of this infection vary widely from asymptomatic infection to uncomplicated acute viral hepatitis and fulminant hepatic failure. The pathogenesis of this disease and the reason of varying disease seve...

journal_title：Journal of gastroenterology and hepatology

authors： Srivastava R,Aggarwal R,Sachdeva S,Alam MI,Jameel S,Naik S

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND AIM:There is scanty data on the occurrence of celiac disease in patients with type 1 diabetes mellitus in South Asia. Our aim was to study the prevalence and clinical profile of celiac disease in patients with type 1 diabetes mellitus in a tertiary care referral centre in north India. METHODS:Consecutiv...

journal_title：Journal of gastroenterology and hepatology

authors： Bhadada SK,Kochhar R,Bhansali A,Dutta U,Kumar PR,Poornachandra KS,Vaiphei K,Nain CK,Singh K

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND AIM:Liver stiffness measurement (LSM) with transient elastography is a non-invasive and reliable test for liver fibrosis. However a small proportion of patients may have unreliable LSM or LSM failure. The aim of the present study was to investigate the factors associated with unreliable LSM or LSM failur...

journal_title：Journal of gastroenterology and hepatology

authors： Wong GL,Wong VW,Chim AM,Yiu KK,Chu SH,Li MK,Chan HL

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND AND AIM:Esophageal cancer is the second most common cancer among Indian males and is mostly associated with tobacco smoking and alcohol consumption. Epidermal growth factor receptor (EGFR) is a member of Type I tyrosine kinases. Its activation causes the docking of various proteins in its cytosolic tail. In ...

journal_title：Journal of gastroenterology and hepatology

authors： Parthasarathy S,Dhayaparan D,Jayanthi V,Devaraj SN,Devaraj H

更新日期：2011-02-01 00:00:00

abstract：:Hepatic ischemia reperfusion (IR) injury is an important clinical problem complicating liver surgery and transplantation. The pathogenesis underlying reperfusion injury after warm ischemia is complex, encompassing a multitude of different cell types and signalling mechanisms innate and/or mobilized to the liver. Since...

journal_title：Journal of gastroenterology and hepatology

authors： Teoh NC

更新日期：2011-01-01 00:00:00

abstract：:Although the incidence of bleeding from gastric varices is relatively low (10%-36%), the bleeding is massive once it has occurred and it increases the patient's mortality. The management of esophageal variceal bleeding is highly differentiated with several effective treatments available. In contrast, bleeding from gas...

journal_title：Journal of gastroenterology and hepatology

authors： Hashizume M,Akahoshi T,Tomikawa M

更新日期：2011-01-01 00:00:00

abstract：:Interpretation of exploding knowledge about Barrett's esophagus is impaired by use of several conflicting definitions. Because any histological type of esophageal columnar metaplasia carries risk for esophageal adenocarcinoma, the diagnosis of Barrett's esophagus should no longer require demonstration of intestinal-ty...

journal_title：Journal of gastroenterology and hepatology

authors： Dent J

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND AIM:Splenomegaly in a common finding in liver cirrhosis that should determine changes in the spleen's density because of portal and splenic congestion and/or because of tissue hyperplasia and fibrosis. These changes might be quantified by elastography, so the aim of the study was to investigate whether s...

journal_title：Journal of gastroenterology and hepatology

authors： Stefanescu H,Grigorescu M,Lupsor M,Procopet B,Maniu A,Badea R

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND AIMS:Annexin A10 (ANXA10) and its liver-specific short isoform (ANXA10S) had tissue-restricted expression. The downregulation of ANXA10S is correlated with tumor progression and poor prognosis in hepatocellular carcinoma. The aim of the present study was to validate the tissue distribution and explore th...

journal_title：Journal of gastroenterology and hepatology

authors： Lu SH,Chen YL,Shun CT,Lai JN,Peng SY,Lai PL,Hsu HC

更新日期：2011-01-01 00:00:00

abstract：:Hepatocellular adenoma (HCA) is a benign liver neoplasm with a risk of spontaneous bleeding and malignant transformation. The aim of this review article is to review all the case reports and case series of patients with HCA from 1998 to 2008 in China and other parts of the world in order to compare clinical presentati...

journal_title：Journal of gastroenterology and hepatology

authors： Lin H,van den Esschert J,Liu C,van Gulik TM

更新日期：2011-01-01 00:00:00

abstract：BACKGROUND AND AIM:Little is known about the role of hepatitis B virus (HBV) factors in the long-term prognosis of hepatocellular carcinoma (HCC) after resection. The objective of the present study was to identify the changing patterns of HBV levels and its effect on outcome after resection. METHODS:This study recruit...

journal_title：Journal of gastroenterology and hepatology

authors： An HJ,Jang JW,Bae SH,Choi JY,Cho SH,Yoon SK,Han JY,Lee KH,Kim DG,Jung ES

更新日期：2010-12-01 00:00:00

abstract：BACKGROUND AND AIMS:The binucleation of hepatocytes, which was known as an important feature of liver growth and physiology, has been reported to be increased during the chronic oxidative injury stage and has been regarded as an age-related change of hepatic structures. Therefore, we investigated the binuclearity patte...

journal_title：Journal of gastroenterology and hepatology

authors： Park JK,Hong IH,Ki MR,Chung HY,Ishigami A,Ji AR,Goo MJ,Kim DH,Kwak JH,Min CW,Lee SS,Jeong KS

更新日期：2010-11-01 00:00:00

abstract：BACKGROUND AND AIMS:Serum alanine aminotransferase (ALT) is commonly used to detect liver damage. Recent studies indicate that ALT levels at the upper range of normal limits are predictors of adverse outcomes, especially diabetes mellitus (DM) and the metabolic syndrome. The aim of our study was to define the ALT thres...

journal_title：Journal of gastroenterology and hepatology

authors： Shlomai A,Kariv R,Leshno M,Beth-or A,Sheinberg B,Halpern Z

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND AIM:6-Mercaptopurine (6-MP) and azathioprine (AZA) are widely used as maintenance therapy in children with inflammatory bowel disease (IBD). However, proper 6-thioguanine nucleotide (6-TGN) concentrations in Japanese children with IBD have not been reported. METHODS:This retrospective review examines 32...

journal_title：Journal of gastroenterology and hepatology

authors： Ohtsuka Y,Arai K,Aoyagi Y,Fujii T,Yamakawa Y,Ohtani K,Ikuse T,Baba Y,Inage E,Kudo T,Suzuki R,Nagata S,Shimizu T

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND AND AIM:To validate an early discharge policy in patients admitted with upper gastrointestinal bleeding (UGIB) due to ulcers. METHODS:Patients with gastroduodenal ulcer or erosive gastritis/duodenitis were included in a previous study aiming to develop a practice guideline for early discharge of patients wi...

journal_title：Journal of gastroenterology and hepatology

authors： Chaparro M,Barbero A,Martín L,Esteban C,Espinosa L,de la Morena F,Sánchez A,Martín I,Santander C,Moreno-Otero R,Gisbert JP

更新日期：2010-09-01 00:00:00

abstract：BACKGROUND AND AIM:Portal-systemic collateral vascular resistance and vasoconstrictor responsiveness are crucial in portal hypertension and variceal bleeding control. Statins enhance vasodilators production, but their influence on collaterals is unknown. This study aimed to survey the effect of simvastatin on collatera...

journal_title：Journal of gastroenterology and hepatology

authors： Huang HC,Wang SS,Lee JY,Chen YC,Lee FY,Lin HC,Chang CC,Lee SD

更新日期：2010-08-01 00:00:00

abstract：BACKGROUND AND AIM:Locoregional therapies for hepatocellular carcinoma (HCC) are considered to confer a survival advantage, however, the patient group that should be targeted is not clearly defined. This study aimed to determine the impact on survival of locoregional therapies compared with supportive care, within prog...

journal_title：Journal of gastroenterology and hepatology

authors： Mahady SE,Charlton B,Fitzgerald P,Koorey DJ,Perry JF,Waugh RC,McCaughan GW,Strasser SI

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND AIM:Controversy continues as to whether nutcracker esophagus (NE) is a 'real' manometric disease due to its poor correlation with clinical symptoms such as chest pain or dysphagia. While new NE criteria were proposed in a recent study, that study included NE patients both with and without gastroesophagea...

journal_title：Journal of gastroenterology and hepatology

authors： Jung KW,Jung HY,Yoon IJ,Kim DH,Chung JW,Oh HC,Choi KS,Choi KD,Song HJ,Lee GH,Kim JH

更新日期：2010-07-01 00:00:00

abstract：BACKGROUND AND AIM:Reactive oxygen species produced by cytochrome P4502E1 (CYP2E1) are believed to play a role in pathophysiology of non-alcoholic fatty liver disease (NAFLD). However, little is known about the expression, protein content and activity of anti-oxidant enzymes and the role of inducible nitric oxide synth...

journal_title：Journal of gastroenterology and hepatology

authors： Kathirvel E,Chen P,Morgan K,French SW,Morgan TR

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND AIM:A substantial number of patients with gastroesophageal reflux disease show symptomatic resistance to high-dose proton pump inhibitors. In those cases, prokinetics are possible candidates for treatment. The aim of the present study was to determine whether mosapride, a prokinetic agent, stimulates eso...

journal_title：Journal of gastroenterology and hepatology

authors： Koshino K,Adachi K,Furuta K,Ohara S,Morita T,Nakata S,Tanimura T,Miki M,Kinoshita Y

更新日期：2010-06-01 00:00:00

abstract：BACKGROUND AND AIMS:Resistance of Helicobacter pylori to the standard therapeutic antimicrobial agents has been demonstrated. Although quinolones are an alternative candidate for third-line eradication therapy, quinolone resistance of H. pylori is also increasing. Quinolone resistance of H. pylori is caused by a point ...

journal_title：Journal of gastroenterology and hepatology

authors： Matsuzaki J,Suzuki H,Tsugawa H,Nishizawa T,Hibi T

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND AIMS:According to reports in Japanese patients, 1 week of Helicobacter pylori eradication therapy alone is not adequate for healing of gastric ulcers; 7-8 weeks of anti-ulcer therapy are subsequently required. We compared a gastroprotective drug, sofalcone, and an H(2)-receptor antagonist, cimetidine, in...

journal_title：Journal of gastroenterology and hepatology

authors： Higuchi K,Watanabe T,Tanigawa T,Tominaga K,Fujiwara Y,Arakawa T

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND AIMS:Mongolian gerbils are frequently used to study Helicobacter pylori-induced gastritis and its consequences. The presence of some gastric flora with a suppressive effect on H. pylori suggests inhibitory microflora against H. pylori infection. The aim of the present study was to analyze the microflora ...

journal_title：Journal of gastroenterology and hepatology

authors： Zaman C,Osaki T,Hanawa T,Yonezawa H,Kurata S,Kamiya S

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND AIM:The incidence of colorectal cancer (CC) is increasing in many Asian countries, but decreasing in western countries. The present study examined the local incidence of CC in the past few decades. METHODS:A population based study, using data from Hong Kong (HK) Cancer Registry, was carried out to exami...

journal_title：Journal of gastroenterology and hepatology

authors： Yee YK,Gu Q,Hung I,Tan VP,Chan P,Hsu A,Pang R,Lam CS,Wong BC

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND AIM:Some patients with chronic hepatitis C experience virologic relapse even after achieving an end of treatment response. Prolonged therapy can be effective for helping such high-risk patients to avoid relapse. We aimed to identify factors predictive of virologic relapse in chronic hepatitis C patients ...

journal_title：Journal of gastroenterology and hepatology

authors： Shin SR,Sinn DH,Gwak GY,Choi MS,Lee JH,Koh KC,Yoo BC,Paik SW

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND:Currently, hepatitis B immunoglobulins (HBIg) and/or lamivudine have become the main options for prevention of hepatitis B recurrence after liver transplantation. AIM:To assess the benefits of HBIg and/or lamivudine for prevention of hepatitis B recurrence after liver transplantation. METHODS:We conducted ...

journal_title：Journal of gastroenterology and hepatology

authors： Chen J,Yi L,Jia JD,Ma H,You H

更新日期：2010-05-01 00:00:00

abstract：BACKGROUND AND AIM:The risk for erosive esophagitis (EE) with low-dose aspirin (ASA) remains unknown, especially among Japanese patients. We conducted the present study to compare the risk of EE with that of gastroduodenal mucosal injury among Japanese patients taking ASA. METHODS:From 5555 patients undergoing upper g...

journal_title：Journal of gastroenterology and hepatology

authors： Yamamoto T,Mishina Y,Ebato T,Isono A,Abe K,Hattori K,Ishii T,Kuyama Y

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND AIM:The present study aims to explore if and when acid (pH) refluxes can predict refluxes detected by multichannel intraluminal impedance (MII) studies. This correlation may indicate whether pH probe-only and MII-pH studies are interchangeable. METHODS:Prospective observational cross sectional study of ...

journal_title：Journal of gastroenterology and hepatology

authors： Misra S

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND AIMS:Th17 cells have been shown to mediate host defensive mechanisms in various infections, but their role in HBV infection in humans has not been well characterized. In this study, we analyzed the frequency and cytokines secretion of circulating Th17 cells in HBV infected patients with different statuse...

journal_title：Journal of gastroenterology and hepatology

authors： Wu W,Li J,Chen F,Zhu H,Peng G,Chen Z

更新日期：2010-04-01 00:00:00

abstract：BACKGROUND AND AIM:Colorectal cancer screening is recommended for average-risk persons beginning at age 50. However, information about the incidence and risk factors of precursor adenoma in preceding decades is limited. The aim of this study was to determine the prevalence and risk factors of colorectal adenoma in pers...

journal_title：Journal of gastroenterology and hepatology

authors： Chung SJ,Kim YS,Yang SY,Song JH,Park MJ,Kim JS,Jung HC,Song IS

更新日期：2010-03-01 00:00:00

abstract：BACKGROUND AND AIMS:To evaluate and compare laparoscopic splenectomy and partial splenic embolization as supportive intervention for cirrhotic patients with hypersplenism to overcome peripheral cytopenia before the initiation of and during interferon therapy or anticancer therapy for hepatocellular carcinoma. METHODS:...

journal_title：Journal of gastroenterology and hepatology

authors： Tomikawa M,Akahoshi T,Sugimachi K,Ikeda Y,Yoshida K,Tanabe Y,Kawanaka H,Takenaka K,Hashizume M,Maehara Y

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND AIM:In hilar cholangiocarcinoma, an accurate assessment of preoperative resectability is important to optimize surgical resection. We investigated the accuracy of the combination of intraductal ultrasonography (IDUS) and percutaneous transhepatic cholangioscopy (PTCS) for evaluating longitudinal extent i...

journal_title：Journal of gastroenterology and hepatology

authors： Kim HM,Park JY,Kim KS,Park MS,Kim MJ,Park YN,Bang S,Song SY,Chung JB,Park SW

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND AIM:The role of zinc in the nutrition and growth of children with chronic liver disease is poorly defined. The present study determined the serum zinc levels of children with compensated liver disease (CLD) and decompensated liver disease (DLD) and compared this with healthy children. Zinc levels were al...

journal_title：Journal of gastroenterology and hepatology

authors： Umusig-Quitain P,Gregorio GV

更新日期：2010-02-01 00:00:00

abstract：BACKGROUND AND AIM:Histological criteria for intracapsular venous invasion (IVI) that would allow its discrimination between portal and hepatic venous invasion in hepatocellular carcinoma (HCC) have not been established. METHODS:We evaluated IVI immunohistochemically to discriminate between portal and hepatic venous i...

journal_title：Journal of gastroenterology and hepatology

authors： Ohashi M,Wakai T,Korita PV,Ajioka Y,Shirai Y,Hatakeyama K

更新日期：2010-01-01 00:00:00

abstract：:The prevalence of colorectal cancer is increasing in Asia. However, the age-standardized rate has reached a plateau in some countries. Some studies have shown a male predominance difference and increasing risk in the elderly, but not in the younger population. 'Right shifting' of colorectal cancer, not accountable by ...

journal_title：Journal of gastroenterology and hepatology

authors： Yee YK,Tan VP,Chan P,Hung IF,Pang R,Wong BC

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND AIMS:There is a paucity of literature regarding the clinical profile of chronic pancreatitis (CP) in children. The aims of this retrospective study were to determine the etiology and clinical presentation, and to present our experience in diagnosing CP in children in China. METHODS:Clinical data of chil...

journal_title：Journal of gastroenterology and hepatology

authors： Wang W,Liao Z,Li ZS,Shi XG,Wang LW,Liu F,Wu RP,Zheng JM

更新日期：2009-12-01 00:00:00

abstract：BACKGROUND AND AIM:Disease activity and severity of ulcerative colitis (UC) is assessed using colonoscopy, which is invasive, costly and has poor patient acceptability. The role of non-invasive biomarkers of intestinal inflammation in the evaluation of patients with UC is not known. The aim of the study was to examine ...

journal_title：Journal of gastroenterology and hepatology

authors： Masoodi I,Kochhar R,Dutta U,Vaishnavi C,Prasad KK,Vaiphei K,Kaur S,Singh K

更新日期：2009-11-01 00:00:00